CD8 + T Cells from Human Neonates Are Biased toward an Innate Immune Response
Cell Rep. 2016-11-15;17(8):2151-2160.
- Abstract
- To better understand why human neonates show a poor response to intracellular pathogens, we compared gene expression and histone modification profiles of neonatal naive CD8+ T cells with that of their adult counterparts. We found that neonatal lymphocytes have a distinct epigenomic landscape associated with a lower expression of genes involved in T cell receptor (TCR) signaling and cytotoxicity and a higher expression of genes involved in the cell cycle and innate immunity. Functional studies corroborated that neonatal CD8+ T cells are less cytotoxic, transcribe antimicrobial peptides, and produce reactive oxygen species. Altogether, our results show that neonatal CD8+ T cells have a specific genetic program biased toward the innate immune response. These findings will contribute to better diagnosis and management of the neonatal immune response.
- Datasets
- DSR561VPG, DSR406ZPK, DSR787UCK, DSR764JTL, DSR507EII, DSR709JUV, DSR453SNM, DSR698VWA, DSR110ZUF, DSR105PRX, DSR215SLE, DSR765TIK, DSR763IUR, DSR919OAF, DSR876QZF, DSR578AKU, DSR474YKA, DSR482BTK, DSR503UYX, DSR905HZY, DSR416SBP, DSR731HOZ, DSR949GHE, DSR325GGW, DSR391QLF, DSR162BYR, DSR892ATI, DSR153JUG, DSR832WUC, DSR668ZGR, DSR537LJY, DSR390HLU, DSR135ZOH, DSR243PTW, DSR776ABK, DSR469IKG, DSR850VAN, DSR628LKG, DSR161PZB, DSR985WAZ, DSR344MRC, DSR660CKE, DSR147EFD, DSR125IUL, DSR239XMV, DSR965SRJ, DSR590GTU, DSR511HYY, DSR774QJV, DSR305QSB, DSR979MLN, DSR570FWI, DSR243WXX, DSR239ZIW, DSR961EJH, DSR319DEE, DSR792IWU, DSR263DMS, DSR632UTY, DSR814BNZ, DSR472GSL, DSR523THA, DSR831WQC, DSR170UDI, DSR349KTQ